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Updated: Jun 21, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
Published on: November 11, 2016
Molecular control of circadian metabolic rhythms
1Department of Cell and Developmental Biology, Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.
Abstract:
Circadian metabolic rhythms are fundamental to the control of nutrient and energy homeostasis, as well as the pathogenesis of metabolic disease, such as obesity, lipid disorders, and type 2 diabetes. This temporal organization of tissue metabolism is coordinated through reciprocal cross talk between the biological timing system and the metabolic regulatory networks. In this review, we discuss the signaling mechanisms that serve to couple metabolic regulation to the circadian pacemaker, in particular the role of the peroxisome proliferator-activated receptor-gamma coactivator-1 transcriptional coactivators in integrating clock and energy metabolism.
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