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Updated: Jun 21, 2026
Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Population-based incidence of macular holes
Colin A McCannel1, Jennifer L Ensminger, Nancy N Diehl
1Jules Stein Eye Institute, Department of Ophthalmology, UCLA David Geffen School of Medicine, Los Angeles, California 90095, USA. cmccannel@jsei.ucla.edu
Purpose:
To determine the incidence of full-thickness macular holes in Olmsted County, Minnesota.
Design:
Population-based retrospective chart review (cross-sectional study).
Participants:
Ninety-four eyes of 85 patients who were residents of Olmsted County, Minnesota.
Methods:
A population-based retrospective chart review was performed for all diagnoses of macular hole between 1992 and 2002 among residents of Olmsted County, Minnesota. Yearly incidence rates for each given age and sex group were determined by dividing the number of cases within that group by the estimated total Olmsted County resident population of the group for that given year.
Main Outcome Measures:
Documented clinical diagnosis of a macular hole.
Results:
Idiopathic macular holes occur at an age- and sex-adjusted incidence in 7.8 persons and 8.69 eyes per 100,000 population per year in Olmsted County, Minnesota. The female-to-male ratio was determined to be 3.3 to 1, and bilateral idiopathic macular holes occurred in 11.7% of patients and accounted for 20.9% of the affected eyes.
Conclusions:
This study uniquely determined the incidence of macular holes in a predominantly Caucasian population.
