[Synthesis and cerebral vasodilating effects of tetrahydro-pyrido [1,2-a] indole derivatives]

A series of 2-substituted-6-oxo-10-[2-(N-substituted)carbamoyl]ethyl- 6,7,8,9-tetrahydro-pyrido[1,2-a]indole compounds were synthesized for studying the relation between structures and cerebrovascular activities. The structures of compounds synthesized were confirmed by means of 1HNMR, MS, IR, UV and elemental analysis. Preliminary pharmacological experiments showed that all these new compounds were effective for cerebral vasodilation. Compound I7 was the best of all. The beta-diethylaminoethylamine moiety seems to be better than beta-dimethylaminoethylamine.