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[Research on nifedipine patch].

L P Ruan1, J M Zheng

  • 1Department of Pharmaceutics, Shenyang College of Pharmacy.

Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|January 1, 1991
PubMed
Summary
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This study established a method to test nifedipine patches, showing they deliver the drug effectively over time. The nifedipine patches achieved therapeutic levels in plasma for extended periods.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Pharmacokinetics

Context:

  • Nifedipine is a crucial medication for cardiovascular conditions.
  • Transdermal drug delivery offers advantages over oral administration.
  • Developing effective nifedipine transdermal patches is an area of pharmaceutical research.

Purpose:

  • To assess the feasibility of a matrix dispersion-type nifedipine patch.
  • To establish an HPLC method for quantifying nifedipine in vitro and in vivo.
  • To evaluate the pharmacokinetic profile and skin permeation characteristics of the nifedipine patch.

Summary:

  • Two nifedipine patch formulations (R1 without azone, R2 with azone) demonstrated zero-order permeation kinetics.
  • Skin permeation rates differed post 10.25 hours, with R2 showing higher initial flux.

Related Experiment Videos

  • The R2 formulation followed a linear Q vs t1/2 release profile, achieving therapeutic plasma levels in subjects for 23 hours.

    • Impact:

    • The developed HPLC method is suitable for nifedipine quantification in pharmacokinetic studies.
    • The nifedipine patch demonstrates potential as a viable transdermal delivery system.
    • This research contributes to the understanding of nifedipine transdermal delivery and its therapeutic application.