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Lung carcinoma in 1,336 patients
K S Sridhar1, W Raub, R C Duncan
1Department of Oncology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, FL 33101.
American Journal of Clinical Oncology
|December 11, 1991
Summary
This study of 1336 lung cancer patients found smoking is prevalent. While survival was linked to local stage and white race, bronchioloalveolar carcinoma showed better outcomes.
Area of Science:
- Oncology
- Epidemiology
- Public Health
Background:
- Lung cancer remains a significant global health challenge.
- Understanding patient demographics and disease characteristics is crucial for effective treatment strategies.
Purpose of the Study:
- To analyze the clinical characteristics and survival outcomes of a cohort of lung cancer patients.
- To identify demographic, histologic, and staging factors associated with lung cancer prognosis.
Main Methods:
- Retrospective analysis of 1336 lung cancer patients diagnosed between 1977 and 1986.
- Data collected from the Tumor Registry of the University of Miami and Jackson Memorial Hospitals.
- Statistical analysis to determine survival predictors and trends in histology and stage.
Main Results:
- The cohort was predominantly smokers (92%), male (69%), and white (68%).
- Squamous cell carcinoma was the most common histology (32%), followed by adenocarcinoma (26%).
- Advanced stage (distant) was observed in 60% of patients; however, bronchioloalveolar carcinoma showed better survival, linked to earlier stage presentation.
Conclusions:
- Local stage and white race were significant predictors of better survival.
- Bronchioloalveolar carcinoma demonstrated a superior survival rate compared to other subtypes.
- Over the study period, there were increases in adenocarcinoma and adenosquamous histologies and distant stage diagnoses.