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Which human leukocyte antigen antibodies are really clinically relevant?

Gerhard Opelz1, Frans H J Claas

  • 1Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany. Gerhard.Opelz@med.uni-heidelberg.de

Human Immunology
|July 8, 2009
PubMed
Abstract

No abstract available in PubMed .

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Antigens Involved in Adaptive Immunity01:26

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...

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