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Updated: Jun 21, 2026

Postoperative Ileus Murine Model
04:26

Postoperative Ileus Murine Model

Published on: July 12, 2024

Postoperative ileus: pathogenesis and treatment.

Thomas J Doherty1

  • 1Department of Large Animal Clinical Sciences, The University of Tennessee College of Veterinary Medicine, 2407 River Drive, Knoxville, TN 37996, USA. tdoherty@utk.edu

The Veterinary Clinics of North America. Equine Practice
|July 8, 2009
PubMed
Summary
This summary is machine-generated.

Post-surgical intestinal ileus is caused by inflammation and motility inhibition. Strategies to reduce its severity include anti-inflammatory drugs, shorter incisions, and limited fluid therapy.

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Murine Ileocolic Bowel Resection with Primary Anastomosis
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Last Updated: Jun 21, 2026

Postoperative Ileus Murine Model
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Published on: July 12, 2024

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
09:44

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

Published on: September 11, 2012

Murine Ileocolic Bowel Resection with Primary Anastomosis
08:49

Murine Ileocolic Bowel Resection with Primary Anastomosis

Published on: October 29, 2014

Area of Science:

  • Gastroenterology
  • Surgical Inflammation
  • Postoperative Ileus

Background:

  • Surgical manipulation of the intestines triggers inflammatory responses, leading to inhibited intestinal motility and postoperative ileus.
  • Factors like endotoxemia, intestinal edema, hypocalcemia, and long incisions exacerbate ileus.
  • Current prokinetic drug treatments for ileus have limited efficacy.

Purpose of the Study:

  • To review the mechanisms contributing to postoperative ileus.
  • To identify strategies for reducing the severity of postoperative ileus.

Main Methods:

  • Review of existing literature on the pathophysiology of postoperative ileus.
  • Analysis of factors contributing to ileus development and exacerbation.
  • Evaluation of potential interventions to mitigate ileus.

Main Results:

  • Intestinal macrophages and leukocytes release cytokines and nitric oxide, inhibiting motility.
  • Excessive fluid therapy, hypocalcemia, and prolonged incisions worsen ileus.
  • Pretreatment with NSAIDs, minimal incision length, reduced manipulation, lidocaine infusion, fluid restriction, and alpha(2) antagonists can reduce ileus severity.

Conclusions:

  • Postoperative ileus results from a complex interplay of inflammatory, mechanical, and metabolic factors.
  • Effective management of ileus requires a multimodal approach focused on prevention and severity reduction rather than solely relying on prokinetic agents.