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Updated: Jun 21, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Interobserver variations in diagnosing asbestosis according to the ILO classification.
Irena Perić1, Katarina Novak, Igor Barisić
1University Hospital of Split and School of Medicine, University of Split, Split, Croatia. irena.peric1@st.t-com.hr
Interpreting chest radiographs for asbestos-related lung disease shows significant variation between doctors. This highlights the need for standardized diagnostic methods beyond the International Labour Office (ILO) classification.
Area of Science:
- Occupational Medicine
- Radiology
- Pulmonary Medicine
Background:
- Asbestos exposure causes asbestosis, lung cancer, and mesothelioma.
- Early diagnosis of asbestosis is challenging.
- Chest radiography is crucial for asbestosis diagnosis.
Purpose of the Study:
- To assess interobserver variability in interpreting chest radiographs for asbestos workers.
- To evaluate the effectiveness of the International Labour Office (ILO) classification system in diagnosing asbestosis.
- To identify areas for improvement in the diagnostic process for asbestos-related lung disease.
Main Methods:
- Cross-sectional study of 318 asbestos-exposed workers over ten years.
- Comparison of chest radiograph interpretations by two independent radiologists using ILO classification.
- Analysis of interobserver variation in classifying lung fibrosis and diffuse pleural thickening.
Main Results:
- Significant interobserver variation was observed in classifying lung fibrosis (26.66% for diameter, 42.2% for profusion).
- Interobserver variation for diffuse pleural thickening reached 34.93%.
- A notable disagreement exists in assessing the severity of pleural and parenchymal asbestos-related pulmonary disease.
Conclusions:
- Current interpretation of chest radiographs for asbestosis shows significant variability.
- The International Labour Office (ILO) classification system requires standardization and improved objectivity.
- High-resolution computed tomography (HRCT) should be considered as an adjunct to current international classification systems.
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