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Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
Published on: August 8, 2019
Nocturia, nocturnal activity, and nondipping.
Rajiv Agarwal1, Robert P Light, Jennifer E Bills
1Indiana University and Veterans' Administration Medical Center, 1481 West 10th Street, Indianapolis, IN 46202, USA. ragarwal@iupui.edu
Hypertension (Dallas, Tex. : 1979)
|July 8, 2009
Summary
Nocturia, or nighttime urination, in chronic kidney disease patients is linked to increased nighttime activity and impaired blood pressure dipping during sleep. This association appears mediated by physical activity, independent of kidney function or diuretic use.
Area of Science:
- Nephrology
- Cardiology
- Sleep Medicine
Background:
- Patients with chronic kidney disease (CKD) often exhibit abnormal blood pressure regulation during sleep (nondipping) and experience nocturia.
- The relationship between nocturia, nocturnal physical activity, and nondipping in CKD patients requires further elucidation.
Purpose of the Study:
- To investigate the association between nocturia, nighttime physical activity, and nondipping in patients with chronic kidney disease.
Main Methods:
- Ninety-eight CKD patients underwent 24-hour ambulatory blood pressure monitoring and wrist actigraphy over two occasions, one month apart.
- Nocturia frequency, nighttime physical activity levels, and blood pressure dipping patterns were assessed.
Main Results:
- Patients with nocturia demonstrated significantly greater nighttime physical activity compared to those without nocturia.
- A higher frequency of nocturia correlated with a reduced drop in physical activity from wake to sleep.
- Nocturia was associated with a significantly lesser fall in systolic blood pressure during sleep (nondipping), mediated by increased nocturnal activity, irrespective of estimated glomerular filtration rate, albuminuria, or diuretic use.
Conclusions:
- Nocturia in CKD patients is linked to increased nocturnal physical activity and impaired blood pressure dipping (nondipping).
- Nighttime physical activity appears to mediate the association between nocturia and nondipping.
- Further research is needed to determine the prognostic significance of nocturia and associated nondipping for cardiorenal events in CKD.
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