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Related Experiment Video

Updated: Jun 21, 2026

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

Intensifying therapy for hypertension despite suboptimal adherence.

Adam J Rose¹, Dan R Berlowitz, Meredith Manze

¹Center for Health Quality, Outcomes, and Economic Research, Boston University School of Medicine, 200 Springs Road, Bedford, MA 01730, USA. adamrose@bu.edu

Hypertension (Dallas, Tex. : 1979)

|July 8, 2009

Summary

Intensifying treatment for high blood pressure (BP) effectively lowers systolic BP regardless of patient adherence. This study suggests treatment intensification benefits all patients, even those with poor adherence.

Related Experiment Videos

Last Updated: Jun 21, 2026

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

Area of Science:

Cardiovascular Medicine
Clinical Pharmacy
Hypertension Management

Background:

Effective blood pressure (BP) control is crucial for hypertensive patients.
Suboptimal patient adherence often complicates treatment intensification (TI) strategies.
The impact of TI on BP outcomes in relation to adherence levels requires further investigation.

Purpose of the Study:

To determine if the effect of treatment intensification on blood pressure varies by patient adherence.
To analyze the association between TI and final systolic blood pressure (SBP) across different adherence quartiles.

Main Methods:

Observational study of 819 hypertensive patients in primary care.
Treatment intensification (TI) calculated as (medication changes - elevated BP visits) / total visits.
Adherence measured using MEMS caps; patients grouped into adherence quartiles or 'missing' adherence.

Main Results:

Overall, each additional TI per 10 visits predicted a 2.0 mm Hg decrease in final SBP (P<0.001).
SBP reduction associated with TI was consistent across all adherence levels, ranging from 1.6 to 2.4 mm Hg.
No statistically significant differences in BP reduction were observed between adherence groups.

Conclusions:

Treatment intensification is associated with similar blood pressure improvements irrespective of patient adherence levels.
Further randomized trials are recommended to confirm optimal management strategies for patients with suboptimal adherence.