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Related Experiment Video

Updated: Jun 21, 2026

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

Published on: July 20, 2014

The role of Src in solid tumors.

Deric L Wheeler¹, Mari Iida, Emily F Dunn

¹Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. dlwheeler@wisc.edu

|July 8, 2009

Summary

Src family kinases (SFKs) are linked to cancer progression and metastasis. Targeting SFK activity offers a promising therapeutic strategy for solid tumors, despite the unclear role of wild-type Src.

Area of Science:

Oncology
Molecular Biology
Biochemistry

Background:

The proto-oncogene c-Src (Src) and related Src family kinases (SFKs) are nonreceptor tyrosine kinases implicated in various cancers.
SFKs interact with numerous signaling pathways, influencing cell proliferation, migration, and survival.
The precise role of wild-type Src in oncogenesis is debated, but elevated SFK activity correlates with advanced malignancy.

Purpose of the Study:

To review the role of SFKs in solid tumor development and progression.
To discuss recent therapeutic advances targeting SFKs in cancer treatment.

Main Methods:

Literature review of studies on SFKs in human cancers.
Analysis of the functional interactions of SFKs with other signaling molecules.

Related Experiment Videos

Last Updated: Jun 21, 2026

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

Published on: July 20, 2014

Examination of therapeutic strategies targeting SFK activity.

Main Results:

Increased SFK protein levels and tyrosine kinase activity are associated with cancer progression and metastasis.
SFKs facilitate cancer progression by modulating other signaling proteins.
SFKs are implicated in diverse biological functions critical for tumor growth and spread.

Conclusions:

SFKs play a significant role in the progression and metastasis of solid tumors.
Targeting SFK tyrosine kinase activity presents a promising therapeutic avenue for cancer treatment.