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Updated: Jun 21, 2026

Simultaneous Label-Free Autofluorescence Multi-Harmonic Microscopy
Published on: August 29, 2025
Picosecond polarized supercontinuum generation controlled by intermodal four-wave mixing for fluorescence lifetime
Pierre Blandin1, Frederic Druon, Marc Hanna
1Laboratoire Charles Fabry de l'Institut d'Optique, CNRS, University Paris-Sud, Palaiseau, France.
Abstract:
We present the generation of a picosecond polarized supercontinuum in highly birefringent multimodal microstructured fiber. The initial steps of the spectral broadening are dominated by intermodal four-wave mixing controlled by the specific fiber design. Using a low repetition rate ultra-stable solid state laser, a pulse train well-suited for versatile time-domain fluorescence lifetime imaging applications is obtained.
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