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Updated: Jun 21, 2026

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva
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Image-guided tissue engineering.

Jeffrey J Ballyns1, Lawrence J Bonassar

  • 1Cornell University, Biomedical Engineering, Ithaca, NY 14853, USA.

Journal of Cellular and Molecular Medicine
|July 9, 2009
PubMed
Summary
This summary is machine-generated.

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Replicating patient anatomy for regenerative medicine implants is challenging. Medical imaging and computer-aided design enable precise, reproducible tissue-engineered constructs for improved medical implants.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Medical Imaging

Background:

  • Replicating complex anatomic shapes for regenerative medicine implants presents a significant challenge.
  • Medical imaging techniques like MRI and CT are increasingly utilized for designing tissue-engineered constructs.

Purpose of the Study:

  • To review available medical imaging modalities for designing tissue-engineered constructs.
  • To present fabrication techniques for producing cellular engineered constructs.
  • To discuss future challenges in image-guided tissue engineering.

Main Methods:

  • Integration of medical imaging (MRI, CT) with computer-aided design (CAD).
  • Application of rapid prototyping technologies for fabricating living implants.

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Last Updated: Jun 21, 2026

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  • Development of methodologies for producing cellular engineered constructs.

    • Main Results:

    • Achieved highly reproducible constructs with spatial resolution up to 25 micrometers.
    • Established a paradigm for selecting appropriate medical imaging techniques.
    • Demonstrated the potential of image-guided approaches in tissue engineering.

    Conclusions:

    • Image-guided tissue engineering, combining medical imaging and rapid prototyping, offers a viable approach for creating patient-specific implants.
    • Further research is needed to address challenges in generating engineered constructs ready for clinical implantation.