Related Experiment Video
Updated: Jun 21, 2026
06:15
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Linear morphea with secondary mucinosis
Sujay Khandpur1, Saurabh Singh, Vinod K Sharma
1Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India. sujaykhandpur@yahoo.co.in
Summary
This study reports a rare case of excessive mucin deposition in morphea, a subtype of scleroderma. This finding challenges typical observations of mucin levels in scleroderma skin lesions.
Area of Science:
- Dermatology
- Pathology
- Rheumatology
Background:
- Mucin deposition is a common skin finding in lupus erythematosus and dermatomyositis.
- It is typically uncommon or minimal in scleroderma.
Observation:
- A 7-year-old boy presented with progressive, linear, bound-down skin plaques on his thighs, lower abdomen, and back.
- No systemic involvement was detected.
Findings:
- Histopathology of the lesions revealed features consistent with scleroderma.
- Abundant mucin deposition was observed in the reticular dermis, which is unusual for morphea.
Implications:
- This case highlights the potential for excessive mucin deposition in morphea.
- It expands the understanding of histopathological variations within scleroderma subtypes.
Related Concept Videos
01:15Secondary Lymphoid Organs
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...