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The pharmacokinetics of oxycodone after intravenous injection in adults
R Pöyhiä1, K T Olkkola, T Seppälä
1Department of Anaesthesia, University of Helsinki, Finland.
British Journal of Clinical Pharmacology
|October 1, 1991
Abstract:
Oxycodone chloride (0.07 mg kg-1) was given by intravenous bolus to nine young adult surgical patients on the first postoperative day. Plasma was sampled for up to 12 h. Mean values of t1/2z, CL and Vss were 222 min, 0.78 l min-1 and 2.60 l kg-1, respectively. The concentrations of the metabolite noroxycodone was also measured. The mean AUC(0,12) ratio of noroxycodone to oxycodone was 0.33. Oxymorphone was not detected.