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Updated: Jun 21, 2026
12:23
Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
Published on: April 24, 2020
Osteoimmunology: crosstalk between the immune and bone systems
Tomoki Nakashima1, Hiroshi Takayanagi
1Department of Cell Signaling, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.
Journal of Clinical Immunology
|July 9, 2009
Summary
Osteoimmunology explores the immune and skeletal systems
Area of Science:
- Osteoimmunology
- Immunology
- Skeletal Biology
Background:
- The interplay between immune and skeletal systems is crucial, particularly in rheumatoid arthritis (RA).
- RA bone destruction involves T helper 17 (TH17) cells inducing receptor activator of nuclear factor-kappaB ligand (RANKL).
- RANKL drives osteoclastogenesis via nuclear factor of activated T cells cytoplasmic 1 (NFATc1).
Purpose of the Study:
- To highlight the dynamic interplay between the immune and skeletal systems.
- To discuss the emergence and evolution of osteoimmunology.
- To explore molecular and cellular interactions in osteoimmunology.
Main Methods:
- Review of existing literature on osteoimmunology.
- Analysis of molecular and cellular interactions.
- Focus on rheumatoid arthritis and bone phenotypes.
Main Results:
- The field of osteoimmunology has rapidly evolved.
- Shared molecules like cytokines, transcription factors, and receptors mediate immune-skeletal interactions.
- RANKL is a key mediator in RA bone destruction.
Conclusions:
- Osteoimmunology encompasses diverse molecular and cellular interactions.
- Understanding these interactions provides a basis for future therapies.
- Future research will target diseases of both immune and skeletal systems.
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