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Updated: Jun 21, 2026
A Mouse Model for Laser-induced Choroidal Neovascularization
Published on: December 27, 2015
Intravitreal anakinra inhibits choroidal neovascular membrane growth in a rat model
Jeffrey L Olson1, Robert J Courtney, Behnaz Rouhani
1University of Colorado Denver, Denver, Colorado, USA. Jeffrey.Olson@UCHSC.edu
Purpose:
To determine the effect of intravitreal anakinra on choroidal neovascularization (CNV) in an animal model.
Methods:
Laser photocoagulation used to rupture Bruch's membrane; animals then assigned to groups based on varying frequency of intravitreal anakinra injections. At day 30, digital angiography was used to measure the CNV area.
Result:
Intravitreal anakinra dose-dependently inhibited CNV growth. Injections given one time resulted in a 26% reduction in CNV; in the once weekly group, a 41% reduction was seen; in the twice-weekly group, a 62% reduction was seen (all p < .001).
Conclusion:
Suppressing IL-1 function may provide another therapeutic avenue in exudative AMD.
