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Published on: August 14, 2015
Effects of carnosine on the evoked potentials in hippocampal CA1 region
Zhou-Yan Feng1, Xiao-Jing Zheng, Jing Wang
1Key Lab of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310003, China. hnfzy@yahoo.com.cn
Objective:
To directly examine the effects of carnosine on neuronal excitation and inhibition in rat hippocampus in vivo.
Methods:
Artificial cerebrospinal fluid with carnosine was directly administrated over the exposed rat hippocampus. The changes of neuron activity in the CA1 region of hippocampus were evaluated by orthodromically- and antidromically-evoked potentials, as well as paired-pulse stimulation paradigm.
Results:
In both orthodromic and antidromic response potentials, carnosine transformed population spikes (PSs) with single spike into epileptiform multiple spikes. In addition, similar to the effect of (-aminobutyric acid(A) (GABA(A)) antagonist picrotoxin, carnosine decreased paired-pulse stimulating depression significantly. However, no significant change was observed in the spontaneous field potentials during the application of carnosine.
Conclusion:
The results indicate a disinhibition-induced excitation effect of carnosine on the CA1 pyramidal neurons. It provides important information against the application of carnosine as a potential anticonvulsant in clinical treatment.
