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Updated: Jun 21, 2026

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Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
Published on: November 21, 2025
Implications of a permanent cardiac pacemaker in peripheral nerve blockade
Baskar P Manickam1, Richard Brull
1Department of Anesthesia and Pain Management, Toronto Western Hospital, University Health Network, Ontario, Canada.
Regional Anesthesia and Pain Medicine
|July 10, 2009
Summary
Patients with permanent pacemakers (PPMs) face risks from operating room equipment. Combining ultrasound and low-current nerve stimulation (NS) offers a safer approach for nerve blocks near PPMs.
Area of Science:
- Anesthesiology
- Biomedical Engineering
- Cardiology
Background:
- Patients with permanent cardiac pacemakers (PPMs) are susceptible to electromagnetic interference (EMI) in operating rooms.
- EMI can cause PPM malfunction, posing risks to patient safety.
- Current peripheral nerve blockade techniques, like nerve stimulation (NS), lack clear safety guidelines for patients with PPMs.
Purpose of the Study:
- To evaluate the safety and efficacy of combined ultrasound and low-current nerve stimulation for peripheral nerve blockade in patients with permanent cardiac pacemakers.
- To address the unknown hazards of conventional nerve stimulation near PPM sites.
Main Methods:
- A combined guidance approach was developed for peripheral nerve blockade.
- Ultrasound was used for precise nerve localization.
- Low-current nerve stimulation was employed for nerve identification.
Main Results:
- The study recommends a combined approach using ultrasound and low-current NS for nerve identification.
- This method aims to mitigate risks associated with EMI and NS near PPMs.
Conclusions:
- A combined ultrasound and low-current nerve stimulation technique provides a safer alternative for peripheral nerve blockade in patients with permanent pacemakers.
- This approach addresses the lack of established guidelines for using NS in the presence of PPMs.
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