Related Experiment Video
Updated: Jun 21, 2026
05:31
Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
Published on: June 8, 2022
Percutaneous pulmonary valve implantation: an update
Philipp Lurz1, Philipp Bonhoeffer, Andrew M Taylor
1UCL Institute of Child Health and Great Ormond Street Hospital for Children, Cardiorespiratory Unit, London, UK. philipp.lurz@gmx.edu
Expert Review of Cardiovascular Therapy
|July 11, 2009
Summary
Percutaneous pulmonary valve implantation (PPVI) is a safe and effective nonsurgical option for treating right ventricular outflow tract dysfunction. This technique can postpone open-heart surgery, reducing lifetime operations for patients with congenital heart disease.
Area of Science:
- Interventional Cardiology
- Congenital Heart Disease Treatment
- Nonsurgical Cardiac Procedures
Background:
- Right ventricular outflow tract/pulmonary trunk dysfunction is common after congenital heart disease repair.
- Existing surgical options carry significant morbidity and mortality.
- There is a need for less invasive, effective treatments for conduit dysfunction.
Purpose of the Study:
- To evaluate the feasibility, safety, and efficacy of percutaneous pulmonary valve implantation (PPVI).
- To assess long-term outcomes of PPVI in patients with right ventricle to pulmonary artery conduit dysfunction.
- To identify complications and areas for future device development in PPVI.
Main Methods:
- Review of 9 years of data on PPVI procedures.
- Analysis of patient outcomes including reoperation, recatheterization, and valve competency.
- Assessment of complications such as stent fractures and endocarditis.
Main Results:
- PPVI is a feasible, safe, and effective treatment for conduit stenosis and regurgitation.
- Median follow-up shows good freedom from reoperation and recatheterization.
- PPVI can postpone the need for open-heart surgery, potentially reducing lifetime surgical burden.
Conclusions:
- PPVI offers a valuable nonsurgical alternative for managing right ventricular outflow tract dysfunction.
- Ongoing research focuses on reducing complications like stent fractures and expanding device applicability.
- Meticulous patient selection and new device development are crucial for optimizing PPVI outcomes.
Related Concept Videos
01:26Mitral Stenosis III: Medical Management
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
01:22Mitral Valve Prolapse II: Assessment and Management
IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular tachycardia.
01:27Mitral Valve Prolapse I: Introduction
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
01:22Mitral Stenosis I: Introduction
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
01:19Mitral Valve Prolapse III: Nursing Management
The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...