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Related Experiment Video

Updated: Jun 21, 2026

Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging
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Pre-target axon sorting establishes the neural map topography.

Takeshi Imai1, Takahiro Yamazaki, Reiko Kobayakawa

  • 1Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 113-0032, Japan.

Science (New York, N.Y.)
|July 11, 2009
PubMed
Summary

Axon guidance molecules, Neuropilin-1 and Semaphorin-3A, control how olfactory sensory neuron axons sort before reaching their targets. This pre-target sorting is crucial for forming accurate topographic maps in the brain.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • Topographic maps in the brain represent peripheral sensory information.
  • Positional cues from target areas were traditionally thought to determine map topography.

Purpose of the Study:

  • To investigate the role of pre-target axon sorting in olfactory map formation.
  • To elucidate the molecular mechanisms underlying axon guidance in the olfactory system.

Main Methods:

  • Analysis of axon sorting in olfactory sensory neurons in mice.
  • Investigated the roles of Neuropilin-1 and Semaphorin-3A in axon guidance.
  • Utilized olfactory sensory neuron-specific knockout models.

Main Results:

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Last Updated: Jun 21, 2026

Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging
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Published on: December 12, 2012

Revealing Neural Circuit Topography in Multi-Color
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  • Expression levels of the axon guidance receptor Neuropilin-1 dictate pre-target axon sorting and projection sites.
  • Complementary expression of Neuropilin-1 and its ligand Semaphorin-3A is critical.
  • Knockout of Semaphorin-3A disrupted axon sorting and altered olfactory map topography.

    • Conclusions:

    • Pre-target axon sorting is essential for establishing topographic order in the olfactory system.
    • The relative levels of guidance molecules expressed by axons are key determinants of map formation.