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Published on: December 9, 2022
Successful treatment of systemic-sclerosis-related digital ulcers with a selective endothelin type A receptor
1Department of Dermatology, University of Heidelberg, Heidelberg, Germany. patrick.gholam@med.uni-heidelberg.de
Abstract:
Digital ulcers represent a major vascular complication of systemic sclerosis (SSc) and can be difficult to treat with the common vasodilators. Herein, we report on a 39-year-old patient with recalcitrant SSc-related digital ulcers treated successfully with sitaxentan (100 mg q.d.), a selective endothelin type A receptor antagonist. During the 6 months of treatment, we noticed a remarkable decrease in pain, a nearly complete healing of the preexistent ulcers and no development of new ulcers. No side effects were noted.
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