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Updated: Jun 21, 2026
03:23
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Published on: May 10, 2024
Unilateral eosinophilic fasciitis: an under-recognized subtype?
Rodney S Daniel1, Sarah Lavery, John C Maize
1Medical University of South Carolina, Division of Rheumatology, Charleston, SC, USA. danielro@musc.edu
Summary
Eosinophilic fasciitis typically affects both limbs symmetrically. This case highlights unilateral eosinophilic fasciitis, emphasizing the need for full-thickness biopsies for accurate diagnosis and treatment.
Area of Science:
- Dermatology
- Rheumatology
- Pathology
Background:
- Eosinophilic fasciitis (EF) is characterized by symmetric skin and fascial inflammation.
- It is often mistaken for scleroderma and its variants.
Observation:
- A patient presented with unilateral, progressive skin thickening.
- A full-thickness skin biopsy revealed inflammatory and fascial changes.
Findings:
- The biopsy findings were consistent with eosinophilic fasciitis.
- This case suggests unilateral EF may be under-recognized.
Implications:
- Accurate diagnosis of unilateral EF is crucial, requiring dermatopathology review of full-thickness biopsies.
- Prompt recognition improves patient prognosis, differentiating it from scleroderma variants with different outcomes.
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