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Updated: Jun 21, 2026

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid
Published on: November 15, 2017
From discovery to production: scale-out of continuous flow meso reactors
Peter Styring1, Ana I R Parracho
1Department of Chemical & Process Engineering, The University of Sheffield, Mappin Street, Sheffield S1 3JD, United Kingdom.
Abstract:
A continuous flow parallel reactor system has been developed to provide a rapid and seamless transition from the discovery phase and production phase of chemical synthesis, particularly in low volume-high value pharmaceuticals production. Using a single fixed bed catalytic meso reactor, reactions can be screened on a small discovery scale over short time scales. The intensified process produces sufficient material for a full analysis. By replication of the single reactor in parallel, the same chemistry can be achieved on a larger scale, on a small footprint and without the mass and heat transport limitations of reactor scale-out in batch.
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