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Related Concept Videos

Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into rapid-acting...
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Hypoglycemia01:26

Hypoglycemia

Hypoglycemia is a blood glucose level below 70 mg/dL. It commonly occurs in individuals using insulin or insulin-secreting drugs, but may also arise in non-diabetic conditions. People with type 1 diabetes are at the highest risk because they depend on exogenous insulin. People with type 2 diabetes are also at risk, especially when treated with insulin or medications such as sulfonylureas, which increase insulin release regardless of blood glucose levels. It develops when insulin levels exceed...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...

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Related Experiment Video

Updated: Jun 21, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

Glycemic control through computerized subcutaneous insulin calculators.

Lorrie K Roemer1, Emerson P Borsato, Nathan C Hulse

  • 1Intermountain Healthcare, Salt Lake City, Utah, USA. Lorrie.Roemer@imail.org

Studies in Health Technology and Informatics
|July 14, 2009
PubMed
Summary
This summary is machine-generated.

Sliding scale insulin (SSI) is reactive and fails to maintain normal blood sugar in hospitals. A new computerized system improves glycemic control by providing patient-specific basal, prandial, and correction insulin doses.

Related Experiment Videos

Last Updated: Jun 21, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

Area of Science:

  • Endocrinology
  • Clinical Informatics
  • Pharmacology

Background:

  • Sliding scale insulin (SSI) is a common but reactive approach to managing blood glucose in hospitalized patients.
  • SSI often fails to maintain euglycemia, leading to suboptimal glycemic control and potential complications.

Purpose of the Study:

  • To describe a computerized decision support application designed to replace SSI in hospitalized patients.
  • To detail the development and components of the application, including insulin calculators and patient-specific order sets.

Main Methods:

  • Development of a novel application integrating four calculators for scheduled (basal and prandial) and correction-factor insulin dosing.
  • Creation of patient-specific order sets, including calculated insulin orders, correction factor tables, and carbohydrate dosing tables.
  • Implementation of the application to replace traditional SSI.

Main Results:

  • The application provides a structured, patient-specific approach to insulin therapy.
  • It aims to offer a more consistent insulin state compared to reactive SSI.
  • The system facilitates improved glycemic control through calculated dosing strategies.

Conclusions:

  • Computerized decision support systems can effectively replace SSI for inpatient glycemic management.
  • This application offers a proactive and individualized strategy for insulin therapy.
  • The system has the potential to enhance patient outcomes by improving blood glucose stability.