Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genetic Screens02:46

Genetic Screens

5.8K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.8K
Pedigree Analysis01:35

Pedigree Analysis

90.4K
Overview
90.4K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K
Cancer Prevention02:59

Cancer Prevention

8.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.6K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

9.8K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.8K
Probability Laws01:49

Probability Laws

44.7K
Overview
44.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adherence to Red Reflex and Vision Screening Recommendations: A Deep Dive into Primary Care Implementation Gaps.

medRxiv : the preprint server for health sciences·2026
Same author

Patient-derived organoids across cancers reveal conserved tumor heterogeneity and actionable therapeutic vulnerabilities.

Science advances·2026
Same author

Understanding capability, opportunity, and motivation for at-home COVID-19 testing in underserved populations during the pandemic.

Translational behavioral medicine·2026
Same author

Navigating the healthcare system with a <i>BRCA1/2</i> pathogenic variant: What do patients value?

Gynecologic oncology reports·2026
Same author

Mixed-Method Formative Evaluation and Cultural Adaptation of Digital Health Communication Content and Delivery Promoting Lung Cancer Screening Shared Decision-Making.

Cancer control : journal of the Moffitt Cancer Center·2026
Same author

Multi-cancer early detection tests: national estimates of awareness and perceived value in the United States.

Cancer causes & control : CCC·2026

Related Experiment Video

Updated: Mar 11, 2026

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
08:15

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

12.7K

Cascade Chatbot: A Scalable Approach to Family-Based Genetic Testing for Hereditary Cancer Syndromes.

Lauren B Davis Rivera1, Lauren Mitchell2, Muhammad Danyal Ahsan2

  • 1Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY.

JCO Clinical Cancer Informatics
|March 9, 2026
PubMed
Summary
This summary is machine-generated.

A new digital chatbot significantly improved cascade genetic testing uptake for hereditary cancer syndromes. This tool effectively engaged relatives, increasing genetic service utilization and aiding precision cancer prevention efforts.

More Related Videos

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.8K
In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

21.4K

Related Experiment Videos

Last Updated: Mar 11, 2026

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
08:15

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

12.7K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.8K
In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

21.4K

Area of Science:

  • Oncology
  • Genetics
  • Digital Health

Background:

  • Cascade genetic testing identifies relatives at risk for hereditary cancer syndromes, but uptake is low due to reliance on patient communication.
  • Clinician-mediated outreach improves efficacy but is resource-intensive, highlighting the need for scalable solutions.

Purpose of the Study:

  • To develop and evaluate a digital cascade chatbot to enhance genetic testing uptake among relatives at risk for hereditary cancer syndromes.
  • To assess the acceptability and effectiveness of a chatbot in delivering education and facilitating access to genetic services.

Main Methods:

  • A quality improvement initiative developed a digital cascade chatbot for gene-specific education and genetic service access.
  • 100 probands with hereditary cancer pathogenic variants were offered the chatbot to share with relatives.
  • Outcomes, including proband acceptance, chatbot sharing, and relative utilization of genetic services, were assessed via telephone follow-up at 2 weeks and 3 months.

Main Results:

  • The cascade chatbot was highly accepted by probands (98.3% acceptance rate among those with untested relatives).
  • Probands effectively shared the chatbot, with 82.8% sharing it with at least one relative by 3 months.
  • Among relatives reached, 51.0% scheduled or completed a genetics appointment, and 73.5% of those completed testing.

Conclusions:

  • A digital cascade chatbot is a highly acceptable and effective tool for engaging relatives in genetic testing.
  • Scalable digital health solutions show promise for improving cascade testing rates and supporting precision cancer prevention strategies.