[Cardiovascular risk and metabolic syndrome at the Toledo Area Study]
J M Martínez Sesmero1, S Bastida, F J Sánchez-Muniz
1Servicio de Farmacia, Hospital Virgen de la Salud, Toledo.
Objectives:
To know the anthropometric and clinical characteristics of a children population sample, to study the prevalence and concurrence of cardiovascular risk factors in that sample, and to define the prevalence of metabolic syndrome in that population considering the blood pressure, HDL cholesterol, and fasting glycemia values, as well as the anthropometrical measurements.
Setting:
The health care area of Toledo.
Subjects:
Children aged 4 years included in the Toledo Area Study.
Interventions:
A prospective study is performed on the metabolic syndrome-related cardiovascular risk factors in a sample of 58 children from the Toledo Area Study. Data on anthropometrical and lipoprotein profile at birth were obtained. The anthropometrical, lipoprotein, and biochemical data were compared with those from other populations; we also looked for possible differences between boys and girls. At the same time, we analyzed the association between several cardiovascular risk factors in that population (logistic regression model) and we set up the cut-off levels to define in the children population possible candidates to metabolic syndrome. These levels are in agreement with those from similar adolescent populations.
Results:
Among the risk factors, higher systolic and diastolic pressure values stand up in girls (93.93 -boys- vs 98.41 -girls- p = 0.058; 52.32 -boys- vs 57.27 -girls- p = 0.026, respectively), as well as the concurrence of high blood pressure and hypercholesterolemia in boys (almost 7%). The whole prevalence of candidates to MS was 10.9% (5 girls -9.1%- and 1 boy -1.8%-). A high percentage of boys (< 50%) presented a wrong diet from the perspective of dietary cardiovascular risk markers. The only statistically significant variable at 10% (p < 0.10) in the regression model was Apo AI.
Conclusions:
It is relevant that the presence of MS is higher in girls and in those infants with a dyslipemic nonhypercholesterolemic profile at birth, which emphasizes the usefulness of cardiovascular risk factors prospection from early ages.
Related Concept Videos
01:30Coronary Artery Disease I: Introduction
01:26Type II Diabetes I: Introduction
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies