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Corneal cell adhesion and proliferation on hydrogel sheets bound with cell-adhesive proteins
1Research Center for Biomedical Engineering, Kyoto University, Japan.
Current Eye Research
|October 1, 1991
Abstract:
The efficiency of protein immobilization to provide a hydrogel surface with a high affinity for corneal epithelial cells was investigated. The cell adhesive proteins collagen and fibronectin, and the cell adhesive oligopeptide RGDS (arginine-glycine-aspartic acid-serine) were successfully covalently immobilized on poly(vinyl alcohol) (PVA) hydrogel sheets. Corneal epithelial cells and L-929 cells were applied to these surfaces. A large number of cells did adhere and proliferate on these protein-bound surfaces in comparison with the virgin PVA not so immobilized.