Related Experiment Video

Updated: Jun 21, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Lipoprotein lipase and premature coronary artery disease

Zhong Chen1, Genshan Ma, Xiaoli Zhang

  • 1Department of Cardiology, Affiliated ZhongDa Hospital of Southeast University, NO. 87 Dingjiaqiao, Hunan Road, Nanjing 210009, PR China. zhongchen7498@sina.com.cn

Acta Cardiologica
|July 15, 2009
PubMed

Insights

Low lipoprotein lipase (LPL) activity and high high-sensitivity C-reactive protein (hs-CRP) predict premature coronary artery disease (CAD) in men. LPL activity is inversely correlated with hs-CRP, indicating a link between inflammation and heart disease risk.

Area of Science:

  • Cardiovascular Medicine
  • Lipid Metabolism
  • Inflammation Research

Background:

  • Premature stable coronary artery disease (CAD) is a significant health concern in male patients.
  • Chronic inflammation and altered lipid metabolism, particularly lipoprotein lipase (LPL) activity, are implicated in CAD development.
  • Understanding the interplay between LPL activity, inflammation, and CAD risk is crucial for effective prevention and treatment strategies.

Purpose of the Study:

  • To investigate the relationship between post-heparin plasma lipoprotein lipase (LPL) activity and chronic inflammation in male patients with premature stable coronary artery disease (CAD).
  • To identify predictors of premature stable CAD in male patients.
  • To explore the association between LPL activity, inflammatory markers, and the severity of coronary artery stenosis.

Main Methods:

  • A case-control study involving 132 male patients (< 55 years) with documented stable CAD and 130 age-matched male controls without CAD.
  • Measurement of post-heparin plasma LPL activity and high-sensitivity C-reactive protein (hs-CRP) levels.
  • Statistical analysis including correlation, multivariate analysis, and assessment of predictors for premature stable CAD.

Main Results:

  • Patients with premature CAD exhibited significantly higher hs-CRP levels and lower LPL activity compared to controls.
  • LPL activity was inversely associated with hs-CRP and triglycerides (TG), and positively associated with HDL-C.
  • Higher hs-CRP, BMI, LDL-C, and hypertension were significant predictors of premature stable CAD; higher LPL activity was protective (OR 0.87). LPL activity decreased with increased coronary stenosis.

Conclusions:

  • Post-heparin plasma LPL activity and hs-CRP are significant, inversely correlated predictors of premature stable CAD in male patients.
  • Reduced LPL activity and elevated hs-CRP are key indicators of increased risk for premature cardiovascular events in men.
  • These findings highlight the importance of assessing LPL activity and inflammatory markers in the management of male patients at risk for early-onset CAD.
Abstract

Related Concept Videos

Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...