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Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
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Published on: May 7, 2019

Thyroidization in renal allografts.

Shinichi Ito1, Akimitsu Kobayashi, Tomohiro Tsuchiya

  • 1Department of Urology, Graduate School of Medical Science, Gifu University, Gifu, Japan. boxter@gifu-u.ac.jp

Clinical Transplantation
|July 15, 2009
PubMed
Summary

Thyroidization, a kidney transplant finding, is linked to urinary tract issues. Early detection and management of these conditions are crucial for better graft survival.

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Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Uropathology

Background:

  • Thyroidization, characterized by Tamm-Horsfall glycoprotein (THP) casts, is a known renal pathology.
  • This finding is common in chronic pyelonephritis and obstructive nephropathy.
  • Thyroidization can also occur in renal allografts, necessitating further investigation.

Observation:

  • A study analyzed 251 renal allograft biopsy specimens from 103 patients.
  • Thyroidization was identified in 16 patients, with varying severity.
  • Associated findings included THP reflux into Bowman's capsule, interstitial THP deposits, and tubulointerstitial nephritis.

Findings:

  • Vesicoureteral reflux (VUR) was present in 3 of 15 patients with thyroidization.
  • Past medical histories revealed low bladder capacity, prostate diseases, and prior urinary tract infections in affected patients.
  • Thyroidization with THP reflux or interstitial deposits suggests underlying urinary tract diseases.

Implications:

  • Subclinical urological diseases in renal allografts may negatively impact graft function and prognosis.
  • Identifying and managing associated urinary tract conditions is essential for optimizing renal allograft outcomes.
  • Further investigation for urinary tract diseases is recommended in transplant patients with thyroidization.