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Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
Published on: September 19, 2017
Polyethylenimine effectively induces, stabilizes, and regulates intramolecular G-quadruplexes
Hongxia Sun1, Qiuju Zhou, Junfeng Xiang
1Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.
Bioorganic & Medicinal Chemistry Letters
|July 15, 2009
Abstract:
The interaction between polyethylenimine (PEI) and telomeric DNA was studied. The results demonstrated that PEI could effectively induce, stabilize, and regulate intramolecular G-quadruplexes. The mechanism for these results has been discussed, and was estimated to be condensation effect of PEI.
