Efficacy of carbamazepine in premenstrual syndromes. A report on four cases

Five patients presented with severe mood disturbance and behaviour change during the premenstruum. Suspiciousness was an important feature in four of them. They were treated with carbamazepine 200-400 mg orally at bedtime for 7 days before the onset of menses. The follow-up period varied from 1 1/2 years to 2 menstrual cycles. Four patients showed remarkable improvement; one patient dropped out because of allergic rash.