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Updated: Jun 21, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
Basic concepts about genes, inactivity and aging
1Health Activity Center, Department of Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA. boothf@missouri.edu
Abstract:
Remarkably, 80-year-old humans who have partaken in lifelong aerobic or strength training have maximal aerobic capacities or muscle strengths comparable with that of sedentary individuals aged 50 or 55-year-old, respectively. Such delays in functional aging are clinically significant because lower aerobic and lower strength capacities increase the risk of premature death. In this short review, we speculate that the lack of daily physical activity induces evolutionarily selected mechanisms to use or lose, one of which is related to nutritional status.
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