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In Vitro Assays to Evaluate the Migration, Invasion, and Proliferation of Immortalized Human First-trimester Trophoblast Cell Lines
Published on: March 5, 2019
Gestational trophoblastic neoplasia: are we compliant with the standards?
B Thirumagal1, D Sinha, R Raghavan
1Department of Obstetrics and Gynecology, City Hospital, Birmingham, UK. tbavananthan@hotmail.com
Abstract:
This study was conducted to assess the management of gestational trophoblastic diseases (GTN) in a district general hospital in accordance with the RCOG guidelines. A retrospective case notes review over a 5-year period found a total of 23 patients treated in this hospital. The annual incidence of hydatidiform mole was 1.3/1,000 deliveries (3,500 deliveries per annum). Ultrasound scanning diagnosed or suspected GTN in only nine of the 23 cases (39%); six women (26%) were diagnosed as missed miscarriage and another six (26%) were diagnosed as incomplete miscarriage. Eleven patients (48%) were not suspected before histological diagnosis. A total of 16 of the 23 cases (70%) were complete moles and the rest were partial moles; 19 of the 23 (83%) were referred to a specialist centre of which 60% were referred within 1 month. The rest were not documented. Contraceptive advice was documented only in 11 case notes (48%). Women with molar pregnancy should be referred to a specialist centre as early as possible and within 2-4 weeks of histological diagnosis, after appropriate counselling and contraceptive advice.
