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Updated: Jun 21, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Pyridinium ylide-assisted one-pot two-step tandem synthesis of polysubstituted cyclopropanes
Qi-Fang Wang1, Xiao-Kai Song, Jiao Chen
1College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Abstract:
A sequential one-pot two-step tandem reaction for efficient synthesis of polysubstituted cyclopropanes has been developed. The three-component reaction of alpha-halogenated methylene compounds, aromatic aldehydes, and acetonitrile derivatives produced first the intermediates pyridinium salts and electron-deficient olefins, followed by cyclopropanation of pyridinium ylide with electron-deficient olefins in situ to afford polysubstituted cyclopropanes. Target compounds were obtained in high yields and were diastereomerically pure after recrystallization.
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