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Updated: Jun 21, 2026

How to Stabilize Protein: Stability Screens for Thermal Shift Assays and Nano Differential Scanning Fluorimetry in the Virus-X Project
Published on: February 11, 2019
Mechanical stability of proteins
1Institute of Physics, Nauka Avenue 46, Kiev 03680, Ukraine. alexander.gabovich@gmail.com
Abstract:
A number of experiments and experimentally based simulations showed that beta-proteins are mechanically more stable than alpha-proteins. However, the theory that might explain this evidence is still lacking. In this paper we have developed a simple elastic theory, which allows to estimate critical forces for stretching both kinds of proteins. It has been shown that unfolding of beta-proteins does really require notably higher forces as compared to the stretching of alpha-proteins.
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