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Clinical update on teriparatide
1Department of Rheumatology, Cleveland Clinic, Cleveland, OH 44195, USA.
Current Rheumatology Reports
|July 17, 2009
Summary
Teriparatide, a parathyroid hormone therapy, effectively treats high-risk fracture patients. This review updates its use, comparing it with antiresorptive agents and exploring optimal treatment strategies.
Area of Science:
- Endocrinology
- Pharmacology
- Orthopedics
Background:
- Teriparatide is an anabolic agent for treating patients at high risk for fracture.
- Its US FDA approval in 2002 followed the Fracture Prevention Trial in treatment-naïve patients.
- New data on antiresorptive agents and parathyroid hormone (PTH) dosing raise questions about optimal teriparatide use.
Purpose of the Study:
- To provide an updated review of teriparatide therapy.
- To compare teriparatide's mechanism of action with antiresorptive agents.
- To discuss current and emerging clinical considerations for teriparatide use.
Main Methods:
- Review of clinical trial data and published literature.
- Comparative analysis of teriparatide and antiresorptive agents.
- Synthesis of information on indications, adverse effects, and combination therapies.
Main Results:
- Teriparatide offers an anabolic mechanism distinct from antiresorptive agents.
- Data suggest varying efficacy and safety profiles depending on timing and duration of therapy.
- Combination therapy and alternative dosing strategies are areas of ongoing research.
Conclusions:
- Teriparatide remains a key anabolic treatment for high-risk fracture patients.
- Optimal use requires careful consideration of patient factors, drug interactions, and treatment sequencing.
- Further research is needed to refine combination therapies and long-term treatment protocols.
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