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Updated: Jun 21, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
l-2,4-Diaminobutyric acid and the GABA system
1Department of Neuropathology, Harvard Medical School and Department of Neuroscience, Children's Hospital Medical Center, Boston, Mass. 02115 U.S.A.
Abstract:
The effects of l-2,4-diaminobutyric acid (DABA) on GABA levels and on the activity of GABA metabolizing enzymes have been studied in a number of rat brain regions after both acute and chronic administration. Kinetic studies indicated that DABA was a non-linear, non-competitive inhibitor of GABA transaminase activity. The DABA-induced elevation of GABA levels paralleled the inhibition of GABA transaminase activity. DABA was a more effective inhibitor of GABA transaminase in vivo than in vitro, and this inhibition probably produced the elevation of GABA levels. The neurotoxicity of DABA appears to produce a use in GABA replacement therapy.
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