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Updated: Jun 21, 2026
Repetitive Transcranial Magnetic Stimulation to the Unilateral Hemisphere of Rat Brain
Published on: October 22, 2016
Brain stimulation reward: Evidence for an adrenergic contribution in the rat
1Mental Health Research Institute, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Mich. 48109 U.S.A.
Abstract:
Two centrally active inhibitors of phenylethanolamine-N-methyltransferase (PNMT: E.C. 2.1.1.28), the terminal enzyme for epinephrine biosynthesis in the brain, and a centrally active blocker of adrenergic synapses produced dose-related decreases in responding for intracranial reward. These decreases occurred at dosage levels which were free from measurable neurologic impairment. The present findings may indicate a possible role for epinephrine-containing neurons in the control of central reward processes.
