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Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...

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Related Experiment Video

Updated: Jun 21, 2026

Determination of Immune Cell Identity and Purity Using Epigenetic-Based Quantitative PCR
08:02

Determination of Immune Cell Identity and Purity Using Epigenetic-Based Quantitative PCR

Published on: February 19, 2020

Quantitative epigenetics: DNA sequence variation need not apply.

Eric J Richards1

  • 1Boyce Thompson Institute for Plant Research, Ithaca, New York 14853, USA. ejr77@cornell.edu

Genes & Development
|July 17, 2009
PubMed
Summary
This summary is machine-generated.

New Arabidopsis populations reveal stable epialleles control complex traits. However, epimutation and transposon activity pose challenges for quantitative epigenetic analysis.

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Last Updated: Jun 21, 2026

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Area of Science:

  • Plant genetics and epigenetics
  • Quantitative trait analysis
  • Arabidopsis thaliana research

Background:

  • Recent studies report the creation of novel Arabidopsis recombinant inbred populations.
  • These populations are designed to emphasize epigenetic variation over genetic variation.

Purpose of the Study:

  • To investigate the role of epigenetic variation in controlling complex quantitative traits.
  • To assess the utility of engineered populations for epigenetic studies.

Main Methods:

  • Construction of Arabidopsis recombinant inbred populations maximizing epigenetic variation.
  • Analysis of phenotypic variation distribution and behavior within these populations.

Main Results:

  • Phenotypic variation patterns suggest stable epialleles can influence complex quantitative traits.
  • Stochastic epimutation and transposon movement were observed as technical challenges.

Conclusions:

  • Stable epialleles are implicated in the control of complex quantitative traits in Arabidopsis.
  • Technical hurdles related to epimutation and transposon activity need to be addressed for quantitative epigenetic analysis.