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Updated: Jun 21, 2026
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A Novel Three-dimensional Flow Chamber Device to Study Chemokine-directed Extravasation of Cells Circulating under Physiological Flow Conditions
Published on: July 15, 2013
Infiltration and extravasation: update on prevention and management
Darcy Doellman1, Lynn Hadaway, Leigh Ann Bowe-Geddes
1Cincinnati Children's Hospital, Cincinnati, Ohio 45229, USA. darcy.doellman@cchmc.org
Summary
Infiltration and extravasation during IV therapy can cause severe tissue damage. Prompt intervention and adherence to protocols are crucial for preventing complications and ensuring patient safety.
Area of Science:
- Medical Science
- Patient Safety
- Intravenous Therapy
Background:
- Infiltration and extravasation are risks associated with intravenous (IV) administration.
- These events involve unintended leakage of IV solutions into surrounding tissues.
- Consequences can range from minor local irritation to severe outcomes like amputation.
Purpose of the Study:
- To highlight the risks and consequences of IV infiltration and extravasation.
- To emphasize the importance of immediate and appropriate clinical interventions.
- To underscore the role of established policies and timely surgical management.
Main Methods:
- Review of potential complications from IV therapy.
- Analysis of immediate management strategies for infiltration and extravasation.
- Discussion of preventative measures through policy adherence.
- Evaluation of the necessity and timing of surgical intervention.
Main Results:
- Immediate actions like dilution, extraction, antidotes, and supportive care can mitigate injury.
- Adherence to established policies and procedures is key to preventing many injuries.
- Timely surgical intervention is critical for managing severe adverse outcomes.
- Prompt clinical action upon event occurrence is essential.
Conclusions:
- Effective management of IV infiltration and extravasation requires prompt action and adherence to protocols.
- Preventative measures and timely interventions, including surgery when needed, are vital for minimizing patient harm.
- Thorough incident documentation is crucial for quality assessment and medicolegal defense.
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