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Updated: Jun 21, 2026
Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation
Published on: May 12, 2008
A conventional route to scalable morphology-controlled regular structures and their superhydrophobic/hydrophilic
Hong-Xuan Ren1, Xing Chen, Xing-Jiu Huang
1School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210098, PR China.
Abstract:
We use a conventional and straightforward route to fabricate scalable morphology-controlled regular structures. This route is based on the etching of PDMS microlens array in CF4 and CF4/O2 plasma. PDMS microlens array can be changed to regularly isolated microdot structures array in CF4 plasma. Microbowl shaped structures array can be reached in CF4/O2 plasma. Moreover, a set of structures after CF4 plasma treatment display superhydrophobicity, while a set of structures after CF4/O2 plasma treatment present hydrophilicity. DNA molecules can be readily enriched on the hydrophilic surface. We believe that the regular structure array surfaces provide a useful inspiration towards biomolecular detection and transportation in biochips.
