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Updated: Jun 21, 2026
07:05
Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
[Circulating bone marrow-derived stem cells in patients with polypoidal choroidal vasculopathy]
Atsushi Otani1, Manabu Sasahara, Yuko Yodoi
1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Japan. otan@kuhp.kyoto-u.ac.jp
Nippon Ganka Gakkai Zasshi
|July 18, 2009
Summary
Impaired circulating bone marrow (BM)-derived stem cells were found in polypoidal choroidal vasculopathy (PCV) patients, especially those with bilateral or larger lesions. This suggests a role for these stem cells in PCV development.
Area of Science:
- Ophthalmology
- Stem Cell Biology
- Regenerative Medicine
Context:
- Polypoidal choroidal vasculopathy (PCV) is a subtype of neovascular age-related macular degeneration (AMD).
- The pathogenesis of PCV is not fully understood.
- Circulating bone marrow (BM)-derived stem cells are implicated in various regenerative processes.
Purpose:
- To investigate the functional capacity of circulating BM-derived stem cells in patients with PCV.
- To determine if impaired stem cell function correlates with disease severity or laterality in PCV.
Summary:
- Thirty-one PCV patients were studied, analyzing circulating BM-derived stem cells.
- Colony-forming capacity (CFU-Hill) and migration activity were assessed.
- Reduced CFU-Hill and migration activity were observed in patients with bilateral PCV and larger lesions.
Impact:
- Findings suggest impaired function of circulating BM-derived stem cells in PCV pathogenesis.
- This research may open new avenues for understanding and potentially treating PCV.
- Highlights the potential role of stem cell dysfunction in neovascular AMD subtypes.
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