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Updated: Jun 21, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
[Circulating bone marrow-derived stem cells in patients with polypoidal choroidal vasculopathy]
Atsushi Otani1, Manabu Sasahara, Yuko Yodoi
1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Japan. otan@kuhp.kyoto-u.ac.jp
Purpose:
The current study was designed to investigate the role of circulating bone marrow (BM)-derived stem cells in the pathogenesis of polypoidal choroidal vasculopathy (PCV), a distinct type of neovascular age-related macular degeneration (AMD).
Methods:
Thirty one clinically documented PCV patients were enrolled. Circulating BM-derived stem cells were collected from the patients' peripheral blood and cultured. Colony forming capacity (Hill assay) and migration activity (Boyden chamber system) were examined and analyzed.
Results:
Colony forming units (CFU-Hill) were significantly fewer in bilateral PCV patients than in unilateral PCV patients. CFU-Hill was impaired in patients with larger (> 5000 microm) PCV lesions compared with patients with smaller PCV lesions. Migration activity of BM-derived stem cells was also reduced significantly in the bilateral PCV patients than in the unilateral PCV patients.
Conclusions:
Similar to CNV associated with AMD, impaired functional activity of circulating BM-derived stem cells was observed in PCV patients with bilateral or larger lesions. Circulating BM-derived stem cells may have a role in the pathogenesis of PCV.
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