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Updated: Jun 21, 2026
07:38
Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
Published on: May 10, 2024
Pancreatitis and the broken heart.
Ronak Rajani1, Anna Przedlacka, Mrinal Saha
1Department of Cardiology, Royal Sussex County Hospital, Eastern Road, Brighton BN2 5BE, UK. dr.r.rajani@gmail.com
Summary
A 72-year-old woman developed chest pain and cardiac changes after acute pancreatitis. This case suggests pancreatitis may induce takotsubo cardiomyopathy, a stress-related heart condition.
Area of Science:
- Cardiology
- Gastroenterology
Background:
- Acute pancreatitis is a serious condition with potential systemic complications.
- Takotsubo cardiomyopathy, or stress-induced cardiomyopathy, is typically associated with emotional or physical stress.
Observation:
- A 72-year-old female patient presented with acute pancreatitis.
- Seven days post-admission, she developed acute chest pain, ECG abnormalities, and elevated cardiac enzymes.
- Coronary angiography revealed no obstructive coronary artery disease.
Findings:
- Left ventriculography showed apical akinesia and basal hyperkinesia, characteristic of takotsubo cardiomyopathy.
- This presentation is the first reported instance of takotsubo cardiomyopathy induced by pancreatitis in the literature.
Implications:
- Pancreatitis should be considered a potential trigger for takotsubo cardiomyopathy.
- This finding expands the known spectrum of pancreatitis-induced cardiovascular complications.
- Further research is warranted to elucidate the pathophysiological mechanisms linking pancreatitis and takotsubo cardiomyopathy.
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