Primate disconjugate eye movements during the horizontal AVOR in darkness and a plausible mechanism

Disconjugate eye movements during the horizontal angular vestibulo-ocular reflex (AVOR) evoked in response to steps or pulses of head velocity have been previously reported in lateral eyed animals. In this study, we measured binocular responses to sustained sinusoidal and pseudo-random vestibular stimuli in yaw, delivered in darkness, in both human and monkey. The vestibular stimuli used in our experiments had peak velocities in the range of 120-200 degrees /s, frequencies in the range of 0.17-0.5 Hz, and durations between 60 and 75 s. Our results show a large vergence component to the AVOR response that systematically modulated with head velocity. We also examined our results for temporal-nasal preponderance in slow eye velocity. Although each subject showed some degree of directional preference, we did not find a systematically greater eye velocity for temporal-nasal direction across all subjects. Here, we present these findings and discuss that at least two possible sources could result in disconjugate eye movements during the horizontal rotational VOR in darkness: peripheral and central mechanisms.