Assessment of cardiac function using radionuclide techniques--theory, technical considerations and clinical...

The recent expansion of interventional cardiovascular techniques has stimulated the development of non-invasive cardiac studies, to evaluate the outcome of the interventional therapy. Radionuclide ventriculographic technique provides to quantify global left ventricular systolic/diastolic performance, and evaluate the regional left ventricular wall motion during rest or exercise. This concept was extended from the "bedside" to the ambulatory environment with the description of a battery powered device, the radionuclide ventricular function monitor. To assess the performance of cardiac function using radionuclide ventriculography to that using the ambulatory ventricular function monitor, the systolic and diastolic function were measured at rest in a series of healthy volunteers (n = 10) and in patients with cardiovascular disease (n = 23). Seventeen patients had coronary artery disease (CAD) with prior myocardial infarction, three patients had coronary artery disease, and three patients had dilated cardiomyopathy. The 23 patients manifested a wide variation in LV systolic function. The relationship between the multiple gated acquisition (MUGA)-ejection fraction and the ambulatory ventricular function monitor-ejection fraction correlated well (r = 0.90). As a complement to the radionuclide perfusion studies, cardiac blood pool imaging and radionuclide ventricular function monitoring allow for through non-invasive description of cardiac physiology and function in patients with various cardiac disorders.