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Ultrasound Assessment of Flow-Mediated Dilation of the Brachial and Superficial Femoral Arteries in Rats
Published on: November 3, 2016
Reliability of ultrasonography in detecting flow mediated dilation
Selcuk Pala1, Gokhan Kahveci, Mustafa Akcakoyun
1Department of Cardiology, Kartal Kosuyolu Heart and Research Hospital, Istanbul, Turkey. selcukpalamd@yahoo.com
The International Journal of Cardiovascular Imaging
|July 18, 2009
Summary
Ultrasonography reliably detects brachial artery flow-mediated dilation (FMD), showing high correlation and reasonable agreement with angiography. This study validates ultrasound as a precise tool for FMD assessment.
Area of Science:
- Cardiovascular Imaging
- Vascular Ultrasound
- Diagnostic Accuracy
Background:
- Brachial artery flow-mediated dilation (FMD) is crucial for assessing endothelial function.
- Previous studies reported reproducibility but lacked direct comparison with a reference imaging technique.
Purpose of the Study:
- To evaluate the precision and accuracy of ultrasonography for detecting brachial artery FMD.
- To compare ultrasonographic FMD (USFMD) measurements against simultaneous angiographic FMD (AGFMD).
Main Methods:
- 40 patients undergoing coronary angiography had simultaneous USFMD and selective brachial angiography.
- Measurements were taken at baseline and during reactive hyperemia.
- Linear regression and Bland-Altman analysis assessed precision and accuracy.
Main Results:
- High correlation (r=0.93, P<0.0001) was observed between USFMD and AGFMD.
- The standard error of estimate was 2.7%, with reasonable agreement (95% limits of agreement: -5.481 to 4.674%).
- Mean USFMD was 14.1±7.3% and mean AGFMD was 14.7±7.8%.
Conclusions:
- Ultrasonography demonstrates reliability and accuracy in detecting brachial artery FMD.
- USFMD is a precise method comparable to angiography for FMD assessment.
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