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Related Experiment Videos

High-density lipoprotein particles in octogenarians.

G Luc1, J M Bard, S Lussier-Cacan

  • 1SERLIA, Institut Pasteur, Lille, France.

Metabolism: Clinical and Experimental
|December 1, 1991
PubMed
Summary
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Octogenarians, who survived high coronary heart disease (CHD) risk periods, show elevated levels of Lp A-I particles. This suggests specific high-density lipoprotein (HDL) compositions may offer protection against CHD.

Area of Science:

  • Cardiovascular Science
  • Lipid Metabolism
  • Gerontology

Background:

  • High-density lipoprotein (HDL) particles display heterogeneity in apolipoprotein composition, particularly apo A-I.
  • Two main HDL species exist: Lp A-I/A-II (containing both apo A-I and apo A-II) and Lp A-I (lacking apo A-II).
  • Octogenarians may possess protective factors against coronary heart disease (CHD) due to surviving high-risk periods.

Purpose of the Study:

  • To test the hypothesis that octogenarians have protective factors against CHD.
  • To compare HDL-cholesterol (HDL-C), HDL2-C, HDL3-C, apo A-I, apo A-II, Lp A-I, and Lp A-I/A-II levels between octogenarians and younger controls.

Main Methods:

  • Comparison of lipid and apolipoprotein profiles in octogenarians and younger control subjects (men and women).

Related Experiment Videos

  • Exclusion of participants smoking >10 cigarettes/day or using lipid-altering drugs.
  • Utilized a novel procedure to quantify Lp A-I and Lp A-I/A-II levels.

    • Main Results:

    • In men, total HDL-C was similar, but HDL2-C was higher, and HDL3-C, apo A-I, and apo A-II were lower in octogenarians versus controls.
    • In women, HDL-C and apo A-I were similar between premenopausal and octogenarian groups.
    • Lp A-I levels were significantly higher in both octogenarian men and women compared to their respective younger control groups.

    Conclusions:

    • Octogenarians exhibit distinct HDL particle compositions compared to younger individuals.
    • Elevated Lp A-I levels in octogenarians may represent a protective factor against cardiovascular disease.
    • Further research is warranted to elucidate the role of specific HDL subspecies in longevity and disease resistance.