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Calcium and phosphorus levels in serum and CSF in dementia
M N Subhash1, T S Padmashree, K N Srinivas
1Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Bangalore, India.
Abstract:
Marked differences in CSF levels of both calcium and phosphorus were observed in patients with dementia and aged controls when compared with adult controls. A significant decrease in both Ca and P in CSF was observed in Alzheimer's type dementia (p less than 0.01) and multi-infarct dementia cases (p less than 0.01). The geriatric controls also showed a significant decrease in both Ca and P. A 60% decrease in diffusible Ca in CSF was noted both in patients and geriatric controls when compared to adult controls (p less than 0.001). Diffusible P was also decreased in all three groups (p less than 0.05). A marginal decrease in serum Ca and slight increase in P was observed in both patients and geriatric controls. The significant decrease in CSF Ca and P in both groups of patients compared with aged controls suggests this lowering of Ca and P is not due to solely to the aging process and indicates a role in the pathology of age-related disorders.