Controllable vesicles based on unconventional cyclodextrin inclusion complexes
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Updated: Jun 21, 2026

Rapid Encapsulation of Reconstituted Cytoskeleton Inside Giant Unilamellar Vesicles
Published on: November 10, 2021
Huacheng Zhang1, Jian Shen, Zhaona Liu
1Institute of Organic Chemistry, Jinan, PR China.
Abstract:
Vesicles were assembled from an unconventional inclusion complex between beta-cyclodextrin (betaCD), and N,N'-bis(ferrocenylmethylene)diaminohexane (1). The vesicles formed in water and in a mixed solvent (water/methanol) were observed by transmission electron microscopy. The peculiar inclusion effects of 1.betaCD were characterized by UV and cyclic voltammetry. The structure of the complex was characterized by (1)H- and 2D ROESY NMR spectroscopies. The size of the vesicles in water, methanol, and in mixtures of water and methanol was investigated by dynamic light scattering. The vesicles disappeared upon addition of an oxidizing agent. The structures of the inclusion complex and the vesicles formed via the complex are discussed according to the experimental data.
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